منابع مشابه
Thermodynamics of GPCR activation
G-protein coupled receptors (GPCRs) are the largest family of signaling proteins that are responsible for information input from the extracellular environment. The plasma membrane in which GPCRs reside usually carries an electrostatic membrane potential (DW). This potential and its variations in some cell types are important for cellular functions, including GPCR signaling (Mahaut-Smith et al. ...
متن کاملCyclic AMP-regulated AChR assembly is independent of AChR subunit phosphorylation by PKA.
Forskolin treatment of cells expressing Torpedo acetylcholine receptors leads to enhanced assembly efficiency of subunits, which correlates with increased phosphorylation of the gamma subunit. To determine the role of the two potential protein kinase A sites of the gamma subunit in receptor assembly, cell lines expressing different mutant receptors were established. Mouse fibroblast cell lines ...
متن کاملA review of quantum thermodynamics
In this article, we present a brief and elementary review of quantum thermodynamics and its achievements and challenges. This review includes an introduction to some fundamental concepts such as internal energy, heat, work, entropy, entropy production, thermal equilibrium, second law of quantum thermodynamics, relation between thermodynamics and information theory, as well as a discussion of ho...
متن کاملSrc Kinase Conformational Activation: Thermodynamics, Pathways, and Mechanisms
Tyrosine kinases of the Src-family are large allosteric enzymes that play a key role in cellular signaling. Conversion of the kinase from an inactive to an active state is accompanied by substantial structural changes. Here, we construct a coarse-grained model of the catalytic domain incorporating experimental structures for the two stable states, and simulate the dynamics of conformational tra...
متن کاملClinical application of clustered-AChR for the detection of SNMG
Myasthenia gravis (MG) is an autoantibody-mediated disease of the neuromuscular junction (NMJ). However, accumulating evidence has indicated that MG patients whose serum anti-acetylcholine receptor (AChR) antibodies are not detectable (serumnegative MG; SNMG) in routine assays share similar clinical features with anti-AChR antibody-positive MG patients. We hypothesized that SNMG patients would ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.068